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. 2014 Jun 19;9:12. doi: 10.1186/1745-6150-9-12

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Copyright © 2014 Azuaje; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Examples of top genes with highly significant WNC scores in the GBM network. Genes detected with WNC scores are shown as central nodes with their respective co-expression relationships. Panel A shows an example of gene with significant WNC score (AURKA, P = 0). Example of a gene with a statistically spurious WNC (COL6A3, P =1) is shown in B. Edges are color-coded to reflect the intensity of the gene co-expression values. C: top predicted genes from GBM and KL networks do not overlap, which suggest tissue specificity of the observed associations.