Table 2.

Polymorphisms associated with AIWS or EPSs supported by a meta-analysis or by 3 or more studies reporting the same allele association

Gene	Polymorphism	Main association finding	Study
CYP2D6	metabolizer status	PMs were at higher risk for EPSs in several studies	Kobylecki et al,41 Fu et al,42 Patsopoulos et al43
HTR2C	−759C/T	Two meta-analyzes reported C allele to be associated with larger AIWG	Sicard et al,127 De Luca et al181
LEP	−2548A/G	G allele was associated with higher AIWG in most studies; others showed A allele to be associated	Ellingrod et al,131 Zhang et al,132 Templeman et al182; Zhang et al183
GNB3	−825C/T	T allele was associated with higher AIWG in several studies, and with a nonsignificant trend in a meta-analysis	Ujike et al,129 Wang et al,138 Souza et al184
DRD2	TaqIA	A2 allele was associated with higher risk for TD in 2 meta-analyzes	Bakker et al,48 Zai et al154
DRD3	Ser9Gly	Gly allele was associated with higher risk for TD in several studies	de Leon et al,60 Steen et al,155 Al Hadithy et al,156 Lerer et al,157 Bakker et al158
HTR2A	T102C	C allele was associated with TD in a meta-analysis	Bakker et al,48 Lerer et al164
COMT	Val(108/158)Met	Met allele was protective against TD in a meta-analysis	Bakker et al48
MnSOD	Ala-9Val	Val allele was protective against TD in a meta-analysis	Bakker et al48

Ala = alanine