Table 1. Level of association between carriage of the PlA2 allele and the risk of stroke.

Analysis	Number of studies	Number of cases/controls	Pooled OR* (95% CI)	Association (p value)	I2 (%)
All stroke	25	5,195/6,678	1.12	0.011	56.2
	[18], [19], [27], [29]–[48], [62], [63]		(1.03–1.22)
Ischaemic stroke	22	4,517/5,977	1.15	0.003	55.2
	[18], [19], [27], [30]–[34], [37]–[48], [63]		(1.05–1.27)
Haemorrhagic stroke	4	574/1,047	0.90	0.398	41.1
	[29], [35], [36], [40]		(0.71–1.14)
Subgroup analyses based on genotype:
PlA1/A2 genotype in ischaemic stroke	19	3,948/4,723	1.17	0.003	49.3
	[18], [27], [30]–[34], [38]–[48], [62]		(1.05–1.30)
PlA2/A2 genotype in ischaemic stroke	18	2,666/3,240	1.74	<0.001	70.0
	[18], [27], [30]–[34], [38]–[47], [62]		(1.34–2.26)
PlA2/A2 genotype in haemorrhagic stroke	4	426/748	1.11	0.816	0.0
	[29], [35], [36], [40]		(0.47–2.58)

*OR (odds ratio) calculated using fixed-effects model for carriage of the PlA2 allele versus PlA1 homozygous subjects.

[CI = confidence interval].