Figure 1.

Mean plasma and CSF leptin levels (±SEM) over 33 h in eight subjects depicted as percent of their respective 1000-h baseline levels (left panel). Correlations between plasma and CSF leptin over the 33-h period are shown on the right. The correlation between simultaneously collected plasma and CSF leptin was not significant; however, it became highly significant when CSF leptin levels were back-shifted by 2–5 h to correct for the time delay for CSF flow to the lumbar intrathecal space (right panel).