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Cosinor fit of the plasma and CSF leptin and CSF POMC levels over time. Plasma leptin (upper panel): mesor, 16.1 ng/mL; amplitude, 2.5 ng/mL; acrophase, 2130 h; r2 = 0.808. CSF leptin (middle panel): mesor, 170 pg/mL; amplitude, 10.4 pg/mL; acrophase, 0248 h; r2 = 0.626. CSF POMC (lower panel): mesor, 328 fmol/mL; amplitude, 25.8 fmol/mL; acrophase, 0242 h; r2 = 0.704.
