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. 2014 Apr 8;99(7):2477–2485. doi: 10.1210/jc.2013-3994

Figure 2.

Figure 2.

When compared with placebo, exogenous GIP infusion at a pharmacological dose (20 ng·kg−1·min−1) during a mixed meal in 13 participants with type 2 diabetes is associated with the following: a 5-fold significant increase in plasma GIP levels (A); a significant late postprandial increase in plasma glucose levels (120–220 min) (C); no significant difference in insulin levels (E); a significant early postprandial increase in plasma glucagon (0–60 min) (G); and a significant increase in early postprandial (0–60 min) and late postprandial plasma PP levels (120–360 min) (I). GIP or placebo infusion was started a time 0 and continued for 180 minutes. A mixed meal was given at time 0. Data are presented as mean ± SE. Gray close circle, Placebo; black open circle, GIP. The AUC for GIP (B), glucose (D), insulin (F), glucagon (H), and PP (J) during placebo (gray) and GIP infusion (white) is shown. With fasting values (t = 0) serving as baseline levels, positive AUC and negative AUC corresponded to the area above and below the baseline levels, respectively. The AUC for each curve was divided into different time periods: AUC0–60 (t = 0–60 min), AUC60–120 (t = 60–120 min), AUC120–220 (t = 120–220 min), and AUC220–360 (t = 220–360 min) to better quantify the changes in the response to the placebo vs GIP infusion. ***, P < .001; **, P < .01; *, P < .05.