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. 2014 May 7;57(12):5381–5394. doi: 10.1021/jm500481t

Figure 5.

Figure 5

(A) PfDHODH inhibitor binding site showing limited residues in the 4 Å shell. 6 is shown as ball and stick. Protein–fluorine contacts within 3.4 Å are indicated by dashed lines. (B) Alignment of HsDHODH–6 (turquoise) and rat DHODH (tan) showing the inhibitor binding site. (C) H-bond network between PfDHODH and 6. (D) H-bond network between HsDHODH and 6. (E) H-bond network between rat DHODH and 6. H-bonds are indicated by black dashed lines, and distances are displayed in angstroms.