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Plasma concentration–time curves for (−)-agelastatin A (1a) and 13-debromo-13-trifluoromethyl-agelastatin (1j) after a single (a) 2.5 or (b) 5.0 mg/kg dose (n = 4, error bars indicate standard error). Concentrations of (−)-1a and 1j were determined by LCMS.
