Table 7. Selected Hammett and Taft Parameters for Agelastatin Analogue Substituents.

group	σmetaa	–Esb
CH3	–0.07	1.24
CH(CH3)2		1.71
CH2F	0.12	1.48
CHF2	0.29	1.91
CF3	0.43	2.40
Cl	0.37	0.97
Br	0.39	1.16
I	0.35

^aFrom ref (20a).

^bFrom ref (20b). See ref (20c) for a modified scale of −E_S values.