Table 1.
Potency estimates and comparisons for buprenorphine and methadone across behavioral measures.
| Buprenorphine ED50, mg, i.v. (±95% C.L.) |
Methadone ED50, mg, i.v. (±95% C.L.) |
Potency Ratio (±95% C.L.) |
|
|---|---|---|---|
| Progressive Ratio | |||
| Progressive Ratio | 1.5 (0.0090-7.5) | 8.7 (5.5-20) | 5.0 (3.1-8.0) |
| Visual Analog Scale | |||
| Pay | 4.1 (0.070-6.9) | 17 (5.0-18) | 12 (6.1-20) |
| Good | 5.8 (4.3-8.6) | 14 (9.7-23) | 8.5 (7.3-9.6) |
| High | 7.4 (0.25-5.8) | 16 (13-23) | 8.7 (6.4-11) |
| Liked | 4.9 (3.4-7.2) | 14 (9.5-26) | 8.8 (7.6-10) |
| Quality | 8.6 (0.63-5.9) | 16 (5.4-17) | 4.5 (1.2-18) |
| Potent | 7.6a | 17 (5.4-17) | 4.6 (0.32-55) |
| Drug Effects Questionnaire | |||
| Good Effects | 1.2 (0.65-6.4) | 8.5 (5.7-12) | 5.5 (1.9-15) |
| Like | 0.98 (0.65-7.7) | 6.1 (2.3-23) | 4.4 (1.6-12) |
| Take Again | 1.1 (0.65-6.4) | 7.8 (5.8-21) | 5.3 (1.6-17) |
| Strength | 1.2 (0.73-19) | 7.9 (5.7-18) | 5.0 (2.2-11) |
| Physiological Effects | |||
| Tracking | 0.94 (0.78-8.7) | 20 (5.6-17) | 28 (6.2-131) |
| Maximum Speed | 0.27 (0.67-6.3) | 14 (5.6-18) | 51 (1.7-1500) |
| False Alarms | 2.4 (0.64-6.2) | 14 (5.7-19) | 5.8a |
a
Confidence limits could not be determined for the value