Figure 4. Effects of positive and negative GABAA receptor allosteric modulators on social behaviors and cognitive deficit.
(A and B) Effect of clobazam (0.05 mg/kg) on social interaction behavior of BTBR mice in the three-chamber test (n = 7 – 8).
(C and D) Effect of clobazam (0.05 mg/kg) on BTBR mice (n=7–8) in the open field test on total distance moved (C) and time spent in center (D).
(E and F) Effect of DMCM (0.2 mg/kg) on C57BL/6J mice (n=7–8) in the three-chamber test.
(G and H) Effect of DMCM (0.2 mg/kg) on overall exploratory behavior of C57BL/6J mice (n=8) in the open field test, measured as distance moved (G). Anxiety-like behavior of C57BL/6J mice (n=8) in the elevated plus maze test, measured as time in the open arms (H).
(I and J) Social interaction behavior of BTBR mice (n=6–8) in the 3-chamber test following treatment with the indicated doses of L838417 (I) or zolpidem (J). Test mice were not reused; different groups of mice were used for each dose.
(K and L) Contextual fear conditioning test of BTBR mice (n=5) following treatment with 0.05 mg/kg of L-838,417 (K) or zolpidem (L). Control data were replotted from Figure 2B.
(M) Effect of DMCM (0.2 mg/kg) on 129SvJ mice (n=8) in the three-chamber test.
(N and O) Effects of L838,417 (N) and zolpidem (O) on Scn1a+/− mice in the three-chamber test.
CON, Control. CBZ, Clobazam. CLZ, Clonazepam. All data shown are means ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001.