Table 2. Comparisons of the effects of PI matrix patches of different insulin concentrations on body weight, food and water intake in STZ-induced diabetic rats with untreated diabetic rats and control non-diabetic (ND) animals.
| Time (Weeks) | ||||||
| Parameter | Experimental protocol | 1 | 2 | 3 | 4 | 5 |
| Food intake (g/100 g) | ND control | 10±1 | 9±1 | 10±1 | 10±1 | 11±1 |
| STZ-control | 12±1 | 13±1 | 13±1 | 13±2 | 14±1 | |
| 3.99 | 11±1 | 12±1 | 11±2 | 11±1 | 11±1 | |
| 9.57 | 12±1 | 11±1 | 11±1 | 11±1 | 12±1 | |
| 16.80 | 11±1 | 11±1 | 11±1 | 11±1 | 11±1 | |
| Sc ins | 12±1 | 11±2 | 11±1 | 11±1 | 11±1 | |
| Water intake (ml/100 g) | ND control | 20±1 | 21±2 | 19±1 | 20±1 | 18±1 |
| STZ-control | 58±1* | 59±1* | 62±1* | 63±1* | 64±2* | |
| 3.99 | 56±1* | 56±1* | 40±2* ♦ | 28±1♦ | 22±1♦ | |
| 9.57 | 59±1* | 54±2* | 48±1* ♦ | 29±1♦ | 20±1♦ | |
| 16.80 | 53±1* | 50±1* | 46±2* ♦ | 26±2♦ | 24±1♦ | |
| Sc ins | 54±1* | 48±1* | 38±1* ♦ | 27±1♦ | 18±1♦ | |
| % b.wt changes | ND control | 7±1 | 6±1 | 8±1 | 13±2 | 22±1 |
| STZ-control | −9±1* | −6±2* | −9±1* | −4±2* | −3±1* | |
| 3.99 | −5±1* | −3±1* | 2±1♦ | 4±1♦ | 3±1* ♦ | |
| 9.57 | −3±1* | −2±1* | 4±1♦ | 3±1♦ | 2±1* ♦ | |
| 16.80 | 3±1♦ | 4±1♦ | 4±1♦ | 3±1♦ | 4±2* ♦ | |
| Sc ins | 6±1♦ | 3±1♦ | 4±2♦ | 2±1♦ | 3±1* ♦ | |
Insulin was administered thrice daily for 5-weeks via subcutaneous injection or PI insulin matrices. Data are expressed as mean ± SEM, n = 6 in each group.
*p<0.05 by comparison with control non-diabetic (ND) animals.
♦p<0.05 by comparison with comparison with control STZ-induced diabetic rats.