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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Tissue Antigens. 2014 Jun;83(6):375–381. doi: 10.1111/tan.12381

Figure 1. Potential Therapeutic Interventions for the Pleiotropic Effects of HLA Class I Antibodies on EC.

Figure 1

HLA Class I antibody has several mechanisms by which it can induce endothelial injury including stimulation of EC proliferation, cytoskeletal changes, and migration; the recruitment of leukocytes; chemokine and cytokine production; and stimulation of innate and adaptive alloresponses. This Figure depicts therapeutic intervention to target HLA signaling on the endothelium.