Table 1.
Heritability estimates
| Traita | GCTAb | VC IBDc | Zuk et al.d | Twin studiese | Associated SNPsf |
|---|---|---|---|---|---|
| CRP | 0.02 (0.06)g | 0.08 (0.16) | 0.00 (0.21) | 0.56 (0.07) [W] | 0.041 |
| Glucose | 0.18 (0.07)**,h | 0.39 (0.16)** | 0.51 (0.22)* | 0.67 (0.06) [S] | 0.0165 |
| Insulin | 0.07 (0.07) | 0.04 (0.17) | 0.03 (0.22) | 0.49 (0.05) [S] | 0.0056 |
| Triglycerides | 0.08 (0.07) | 0.00 (0.17) | 0.00 (0.22) | 0.65 (0.05) [W] | 0.0431 |
| HDL | 0.19 (0.07)** | 0.46 (0.17)** | 0.27 (0.22) | 0.76 (0.06) [S] | 0.0638 |
| LDL | 0.29 (0.07)*** | 0.54 (0.17)*** | 0.10 (0.22) | 0.78 (0.05) [S] | 0.06 |
| BMI | 0.16 (0.07)** | 0.00 (0.16) | 0.00 (0.21) | 0.80 (0.03) [W] | 0.0055 |
| Diastolic | 0.08 (0.07) | 0.21 (0.16) | 0.09 (0.21) | 0.51 (0.06) [W] | 0.00 |
| Systolic | 0.06 (0.06) | 0.06 (0.16) | 0.06 (0.21) | 0.47 (0.06) [W] | 0.00 |
aTraits have been transformed to adjust for covariates and achieve approximate normality, as described in Subjects and Methods. Results from the twin studies have not necessarily had the same transformations/adjustments
bEstimates from the GCTA software using autosomal NFBC data
cVariance components approach using IBD-based estimates of relatedness from the autosomal NFBC data
dRegression approach of Zuk et al. using autosomal NFBC data
eIndicative estimates of heritability from twin studies taken from previous literature. Source is denoted by [W] (Wessel et al. 2007) or [S] (Souren et al. 2007). These estimates can differ from the true narrow-sense autosomal heritability of these traits in Northern Finland due to differences in environmental variances, differences in genetic make-up, incorporation of interaction effects or shared environment into family-based estimates, and contribution of the X chromosome
fEstimates of the proportion of trait variation in the NFBC data explained by SNPs significantly associated in the NFBC study or from previous studies are taken from Supplementary Table 4 of Sabatti et al. (2009). These estimates include effects from the X chromosome
gEstimates of heritability are given with standard errors in parentheses
hStatistical significance of estimates from this study are indicated by * (0.01 < p < 0.05), ** (0.001 < p < 0.01), and *** (p < 0.001)