Table 1.
| a. Demographic characteristics of study subjects. | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Diagnostic Groups at baseline | Statisitic (p.value)1 |
D.f | |||||||
| vbFTD | PNFA | SD | CBS | PSP | CI-ND* | Other* | |||
| N (%) | 74 (44.0) | 22(13.1) | 24(14.3) | 11(6.5) | 11(6.5) | 13(7.7) | 13(7.7) | ||
| Age at onset | 66.5±10.2 | 68.6±8.7 | 68.4±11.6 | 67.6±7.5 | 68.3±8 | 70.9±4.9 | 67±9.2 | 0.513 | 6 |
| Gender (%males) | 43(58.1) | 8(36.4) | 18(75) | 8(72.7) | 7(58.3) | 7(53.8 | 5(41.7) | 9.36 | 6 |
| Years evolution before diagnostic (average) | 3.76±2.6 | 2.39±1.6 | 2.96±1.8 | 3.27±2.4 | 3.2±2.5 | 2±1 | 2.42±2.5 | 2.025 | 6 |
| Family History N(%) Yes) | 41(56.9) | 9 (40.9) | 6(25) | 5 (45.5) | 2(16.7) | 9 (69.2) | 3(25) | 17.12 | 6 |
| Education N(%) 6+ years | 48(64.9) | 15(68.2) | 16(66.7) | 6(54.5) | 7(58.3) | 4(30.8) | 5(41.7) | 8.25 | 6 |
| ApoE4 carriers frequency N(%) | 22(29.7) | 3(13.6) | 5(20.8) | 3(27.3) | 2(18.2) | 3(23.1) | 6(46.2) | 5.746 | 6 |
| b. Evolutive phenotype of the groups. | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Evolutive phenotype N(%) |
Diagnostic Groups at baselineN(%) | ||||||||
| bvFTD | PNFA | SD | CBS | PSP | CI-ND | Others | Total | ApoE4 carriers frequency N(%) |
|
| bvFTD | 65(87.8) | 1(4.5) | 2(8.3) | 0 | 0 | 8(61.5) | 6(46.2) | 82 (48.8) | 25(30.5) |
| PNFA | 1(1.4 | 13(59.1) | 0 | 1(9.1) | 0 | 1(7.7) | 1(1.4) | 17(10.1) | 3(17.6) |
| SD | 2(2.7) | 1(4.5) | 21(87.5) | 0 | 0 | 2(15.4) | 0 | 26(15.5) | 5(19.2) |
| FTD-MND | 1(1.4) | 1(4.5) | 0 | 0 | 0 | 1(7.7) | 0 | 3(1.8) | 1(33.3) |
| CBS | 1(1.4) | 2(9.1) | 1(4.2) | 9(81.8) | 0 | 1(7.7) | 4(30.8) | 18(10.7) | 5(27.8) |
| PSP | 1(1.4) | 2(9.1) | 0 | 1(9.1) | 11(100) | 0 | 2(15.4) | 17(10.1) | 3(17.6) |
| AD | 3(4.1) | 2(9.1) | 0 | 0 | 0 | 0 | 0 | 5(3.0) | 2(40.0) |
| Total | 74(44.0) | 22(13.1) | 24(14.3) | 11(6.5) | 11(6.5) | 13(7.7) | 13(7.7) | 168 | 44(26.2) |
vbFTD: behavioral variant Frontotemporal; PNFA: Progressive non Fluent Aphasia; SD: Semantic Dementia; CBS: Corlicobasal Syndrome;PSP Progressive Suplanudear Palsy: CI-ND: Cognitive Impairment non dementia:Other: Unspecific Dementia at baseline
1
- X2 for categorical data, F for continuous data (one-way ANOVA) D.f= degree of freedom 2 —p< .05
*
: Patient initially not classified as FTD who envolved clinical FTD during follow up
bvFTD: behavioral variant Frontotemporal; PNFA: Progressive non Fluent Aphasia: SD: Semantic Dementia; FTD-MND: frontotemporal dementia with motor neuron disease: CBS: Corticobasal Syndrome;PSP: Progressive Suplanuclear Palsy; CI-ND: Cognitive Impairment non dementia Other: Unspecific Dementia at baseline.