Table 3.
Candidates discriminant variables derived from penetrance analysis.
| Variable | APOE Status | Statistics | ||
|---|---|---|---|---|
| E4− | E4+ | χ2 | t | |
| Hemisferic Pattern atrophy (% (N)) | ||||
| Lelf | 34.7 (35) | 8.8 (3) | 0.013 | |
| Right | 10.9(11) | 11.8(1) | ||
| Symmetric | 54.5 (55) | 79.4 (27) | ||
| Predominant Brain atrophy (% (N)) | ||||
| Frontal | 17.8(18) | 32.4(11) | 0.082 | |
| Temporal | 31.7(32) | 20.6 (7) | ||
| Parietal | 3.0 (3) | 11.8(4) | ||
| Fronto-temporal | 30.7(31) | 23.5(8) | ||
| Fronto-parietal | 3.0(3) | 5.9 (2) | ||
| Global | 13.9(14) | 5.9(2) | ||
| Initial symptom reported by caregiver (% (N)) | ||||
| Memory | 35(41) | 50 (20) | 0.094 | |
| Behavior | 41.4(46) | 64.1 (25) | 0.015 | |
| Language | 53.2 (59) | 33.3(13) | 0.033 | |
| Pathological background (% (N)) | ||||
| Dyslipemia | 32.8(38) | 47.5(19) | 0.095 | |
| Neurological exploration (% (N)) | ||||
| Sucking | 1(1) | 5.7 (2) | 0.092 | |
| Normal gait | 66.4 (75) | 81.6(31) | 0.076 | |
| Altered gait | 33.6(38) | 18.4(7) | ||
| Neuropsychological exploration. Quantitative evaluation (average) | ||||
| Visual Naming (15-BNT) | 10.42±3.96 | 12.09±3.34 | 0.036 | |
| Verbal comprehemsion | 4.91±1.3 | 5.53±0.96 | 0.006 | |
| Semantic verbal fluency | 8.48±4.55 | 11.03±3.94 | 0.005 | |
| Similarities WAIS-III | 5.49±3.50 | 7.34±3.60 | 0.016 | |
| Neuropsychological exploration. Qualitative evaluation impaired (% (N)) | ||||
| Poppelreuter test | 48.2(41) | 21.2(7) | 0.007 | |
| Digit Span Forward WAIS-III | 72.2 (65) | 54.5(18) | 0.064 | |
χ2 = Pearson Chi-square
t= Levene for equality of variances