Table 4.
Characteristics of patients as a function of diagnosis and classifier algorithm.
| Diagnosed FTD | Diagnosed AD (AD) |
|||||
|---|---|---|---|---|---|---|
| Classified FTD (FTD) |
Classified AD (fvAD) |
Effect Size (FTD vsfvAD) |
Effect Size (p-value) (AD versus fVAD) |
Effect Size (p-value) (AD versus FTD) |
||
| Demographics | ||||||
| N | 138 | 30 | Na | 332 | Na | Na |
| Age | 70.6±9.8 | 72.8±7.3 | Eta2=0.005(0.3) | 81.4±7.6 | Eta2=0.11(p<0.001) | Eta2=0.29(p<0.001) |
| Education (% <6years) | 37% | 46% | OR=1.4(0.3) | 48% | OR=0.94(0.8) | OR=0.63(0.02) |
| Sex (male %) | 55.8% | 60% | OR= 1.18(0.68) | 25% | OR=4.3 (<0.001) | OR=3.6(<0.001) |
| Mini-Mental State Score | 22.2±6.8 | 22.6±6.2 | Eta2=0.001(0.7) | 19.2±3.9 | Eta2=0.04(<0.001) | Eta2=0.067(<0.001) |
| Family History (% Yes) | 37.2% | 57.1% | OR=2.25(0.06) | 46.6% | OR=1.5(0.28) | OR=0.68(0.08) |
| ApoE4 carriersfrequency N(%) | 35(25.4%) | 9(30%) | Na | |||
| Phenotype | ||||||
| Chief complaints at baseline | ||||||
| Focal Signs | 10% | 3% | P(6df)=1.7E-5 | 0% | P(4df)=0.01 | P(6df)=3E-34 |
| Behavior | 19.6% | 0% | 1.5% | |||
| Gait disturbance | 1.4% | 0 | 0% | |||
| Memory | 34.1% | 90% | 89.2% | |||
| Language | 1.4% | 0 | 0 | |||
| Other | 33.5% | 7% | 9.3% | |||
| Symptoms reported by the caregiver at the beginning of the process | ||||||
| Depression | 8.7% | 0 | P(8df)=6.8E-12 | 1.5% | P(6df)=0.8 | P(8df)=9.5E-47 |
| Job Loss | 0.7% | 0 | 0 | |||
| Focal Signs | 15.2% | 0 | 0.6% | |||
| Behavior | 29.8% | 0 | 3.3% | |||
| Gait disturbance | 2.2% | 0 | 0.6% | |||
| Memory | 20% | 100% | 90.7% | |||
| Language | 1.4% | 0 | 0 | |||
| Others | 22% | 0 | 3.3% | |||
| Predominant signs at baseline | ||||||
| Agitation | 5.0% | 0% | OR=0.80(0.59) | 2.1% | OR=0.92(1) | OR=2.4(0.12) |
| Bulimia | 7.5% | 0% | OR=0.80(0.21) | 0% | Na | OR=0.25(<0.001) |
| Depression | 24.2% | 0% | OR=0.77(0.02) | 24.5% | OR=0.9I(0.001) | OR=0.984(1.0) |
| Disorientation | 26.7% | 29.6% | OR= 1.15(0.81) | 56% | OR=0.33(0.009) | OR=0.28(<0.001) |
| Hypersexuality | 4.2% | 0% | OR=0.81(0.58) | 0% | Na | OR=0.26(0.001) |
| Delusions | 10% | 11.1% | OR=1.1(1) | 10.1% | OR= 1.1 (0.74) | OR=0.99(1) |
| Inhibition | 6.7% | 0% | OR=0.8(0.35) | 1.5% | OR=0.92(1) | OR=4.6(0.008) |
| Memory loss | 71.7% | 96.3% | OR= 10.2(0.005) | 98.5% | OR=0.40(0.381) | OR=0.39(<0.001) |
| Focal sings | 8.3% | 3.7% | OR=0.42(0.69) | 0.3% | OR= 12.5(0.14) | OR=29.6(<0.001) |
| Gait disorder | 10.8% | 0% | OR=0.79(0.12) | 3.7% | OR=0.92(0.61) | OR=3.1(0.009) |
| Language disorder | 46.7% | 33.3% | OR=0.57(0.28) | 25.1% | OR= 1.4(0.3 6) | OR=2.6(<0.001) |
| Neuroimaging data | ||||||
| Symmetry Pattern | ||||||
| Rt. Hemisphere | 14.3% | 4.8% | P(2df)=0.002 | 1.5 | P(2df)=0.15 | P(2df)=5.7E-14 |
| Lt. Hemisphere | 31.3% | 0% | 11.2 | |||
| Symmetric | 54.5% | 95.2% | 87.3 | |||
| Atrophy Location | ||||||
| Frontal | 26.8% | 0 | P(5df)=5.8E-6 | 0.6% | P(7df)=4.5E-29 | P(7df)=4.24E-64 |
| Temporal Pole | 34.8% | 0 | 1.2% | |||
| Parietal | 4.5% | 4.8% | 2.4% | |||
| FrontoTemporal | 21.4% | 66.7% | 2.1% | |||
| Global | 8.9% | 28.6% | 49.5% | |||
| Fronto Parietal | 3.6% | 0 | 0.3% | |||
| Hippocampus | 0 | 0 | 32.3% | |||
| TemporoParietal | 0 | 0 | 11.5% | |||
Note: p-values appear in bracket or alone on each ceil. P-vaiues below 0.0011 are declared significant (Bonferroni’s Correction for multiple comparisons; 43 tests). Df=degree of freedom. Na=Not applicable.