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. 2014 Jul 2;9(7):e101024. doi: 10.1371/journal.pone.0101024

Figure 5. Effects of transplanted ES and iPS cells on cardiac fibrosis.

Figure 5

Representative photomicrographs of interstitial fibrosis (A–E), with fibrotic tissue in blue and healthy cardiac tissue in pink and vascular fibrosis (F–J). Bottom left histogram (K) shows a significant decrease in interstitial fibrosis (mm2) at 2 weeks post-MI in ES and iPS cell treated groups. $p<0.05 vs. Sham; *p<0.05 vs. DOX-MI and DOX-MI+CC; n = 5–7. Bottom middle histogram (L) shows quantitative analysis of vascular fibrosis over total vascular area with a significant decrease in vascular fibrosis percentage in DOX-MI+ES and DOX-MI+iPS groups when compared with DOX-MI and DOX-MI+CC. $p<0.05 vs. Sham; *p<0.05 vs. DOX-MI and DOX-MI+CC; n = 4–6. Bottom right histogram (M) shows quantitative analysis of MMP-9 expression for all treatment groups. $p<0.01 vs. Sham; *p<0.01 vs. DOX-MI and DOX-MI+CC; n = 4–6.