Table 3. Hazard Ratios (95% Confidence Interval) for death due to obesity-related cancer or CVD in relation to change in body size.

				Obesity cancer	related Deathsa , b			CVD	deathsa
	Person-years	Deaths	HR	95% CI	p-value	Deaths	HR	95% CI	p-value
Change in waist circumference (cm)
(−14.5 to 1.0]	25,962	30	1.27	(0.73, 2.23)	0.396	87	1.39	(0.99, 1.97)	0.059
(1.0 to 5.0]	25,775	21	1.00	-	-	53	1.00	-	-
(5.0 to 8.5]	24,022	22	1.19	(0.66, 2.16)	0.565	38	0.84	(0.55, 1.27)	0.408
(8.5 to 13.0]	25,946	16	0.87	(0.45, 1.66)	0.664	38	0.86	(0.57, 1.30)	0.469
(13.0 to 32.5]	23,036	20	1.41	(0.75, 2.64)	0.281	26	0.84	(0.53, 1.35)	0.476
Change in weight (kg)
(−17.8 to −2.3]	24,268	37	1.20	(0.71, 2.02)	0.502	110	2.40	(1.57, 3.65)	≤ 0.001
(−2.3 to 0.7]	25,551	16	0.60	(0.32, 1.15)	0.123	55	1.59	(1.01, 2.52)	0.047
(0.7 to 3.3]	25,076	23	1.00	-	-	27	1.00	-	-
(3.3 to 6.6]	25,054	16	0.76	(0.40, 1.44)	0.404	34	1.49	(0.90, 2.47)	0.123
(6.6 to 24.6]	24,794	17	0.93	(0.49, 1.77)	0.836	16	0.99	(0.53, 1.85)	0.977
Change in hips circumference (cm)
(−15.0 to −1.2]	24,992	31	1.19	(0.69, 2.05)	0.523	79	1.60	(1.09, 2.35)	0.017
(−1.2 to 1.8]	25,027	22	0.87	(0.49, 1.56)	0.651	59	1.27	(0.85, 1.89)	0.246
(1.8 to 4.5]	25,956	24	1.00	-	-	41	1.00	-	-
(4.5 to 8.0]	25,086	19	0.85	(0.47, 1.55)	0.599	34	0.91	(0.58, 1.44)	0.685
(8.0 to 25.8]	23,680	13	0.70	(0.35, 1.37)	0.296	29	0.96	(0.60, 1.56)	0.882

^aEstimates adjusted for sex, country of birth, quintile of socioeconomic status, body size at baseline, cumulative smoking status, and the following covariates measured at baseline and wave 2: physical activity, Mediterranean diet score and living alone.

^bObesity-related cancers include the following cancers: breast, colorectal, endometrial, oesophageal, kidney, pancreatic.