Table 1.
Urine output (UO), free water clearance (C H2O ), urinary excretion of AQP2 (u-AQP2), ENaC (u- ENaC γ ), sodium (u-Na) and potassium (u-K) during a 24-hours urine collection before each examination day in a randomized, placebo-controlled, double-blind, crossover study of 19 healthy subjects
|
Before each examination day |
p (paired t -test) | ||
|---|---|---|---|
| Placebo | Tolvaptan | ||
|
UO (ml/24 h) |
1969 ± 448 |
2025 ± 514 |
0.51 |
|
C
H2O
(ml/min) |
-0.46 ± 0.61 |
-0.47 ± 0.57 |
0.99 |
|
U-AQP2 (ng/min) |
1.10 ± 0.32 |
1.12 ± 0.27 |
0.57 |
|
U-ENaCγ (pg/min) |
716 ± 374 |
705 ± 376 |
0.87 |
|
U-Na (mmol/24 h) |
103 ± 11 |
101 ± 8 |
0.652 |
| U-K (mmol/24 h) | 55 ± 19 | 51 ± 14 | 0.472 |
Data are shown as means with ± SD. Paired t-test was used for comparison between groups.