Table 2. Lead Biomarkers, Serum Iron Indices and Genotypes by Exposure [Mean ± SD or N (%) or M (P25, P75)].
Grouping | Exposed | Unexposed | ||
Males | Females | Males | Females | |
BPb(µg/L) | 384.54±151.98** | 276.16±107.93** | 144.72±60.22 | 139.91±56.84 |
UPb(µg/L) | 39.00(18.00,80.00)** | 28.50(12.00,51.50)** | 3.00(1.00,7.00) | 1.00(1.00,7.50) |
ZPP(µg/gHb) | 9.00±8.92** | 9.03±8.24** | 2.49±1.24 | 4.98±5.79 |
sFe (µmol/L) | 20.97±7.90* | 17.08±7.13 | 24.00±7.93 | 14.74±7.00 |
UIBC(µmol/L) | 37.4±12.4 | 44.2±13.9* | 35.4±12.7 | 51.1±14.8 |
TIBC(µmol/L) | 56.90(51.79, 62.73) | 61.3±10.8 | 57.83(52.65, 65.29) | 65.9±12.1 |
Tf (g/L) | 2.73±0.49 | 2.92±0.54 | 2.87±0.42 | 2.96±0.58 |
TfS (%) | 34.80(26.10, 44.96)* | 28.92±12.84 | 41.37(30.31, 49.68) | 23.39±11.65 |
sFn (µg/L) | 160.00(92.30, 230.00)** | 38.90(20.95, 59.00) | 238.00(148.00, 343.00) | 42.20(20.70, 64.50) |
sTfR (mg/L) | 1.30(1.13, 1.55) | 1.38(1.20, 1.56)* | 1.36(1.12, 1.55) | 1.26(0.99, 1.44) |
BIC (mg/kg) | 40.30±2.63** | 35.22±3.28 | 41.74±2.67 | 35.46±2.69 |
Hb(g/L) | 139.8±15.0 | 120.5±12.2 | 138.3±13.3 | 115.9±14.2 |
H63D | ||||
HH | 546(94.8) | 120(93.0) | 39(90.7) | 21(91.3) |
HD | 29(5.0) | 9(7.0) | 4(9.3) | 2(8.7) |
DD | 1(0.2) | 0 | 0 | 0 |
C282Y | ||||
CC | 576(100) | 129(100) | 43(100) | 23(100) |
CY | 0 | 0 | 0 | 0 |
YY | 0 | 0 | 0 | 0 |
Abbreviations: BPb, blood lead; UPb, urine lead; ZPP, zinc protoporphyrin; sFe, serum iron; UIBC, unsaturated iron-binding capacity; TIBC, total iron binding capacity; Tf, transferrin; TfS, serum transferrin saturation; sFn, serum ferritin; sTfR, soluble transferrin receptor; BIC, body iron content; Hb, haemoglobin. For H63D genotype, HH, wild-type; HD, H63D heterozygous variant; DD, H63D homozygous variant. For C282Y genotype, CC, wild-type; CY, C282Y heterozygous variant; YY, C282Y homozygous variant.
*(**) p<0.05 (0.01) (Chi-square test, Student's t-test or nonparametric test) compared with the unexposed group of the same sex.
Results were expressed as the mean ± SD when continuous variables followed a normal distribution.
Results were expressed as M (P25, P75) when continuous variables did not follow a normal distribution.