Table 1.
T0/T1 Discovery, characterization and development |
T2 Evaluation of tests and interventions |
T3/T4 Implementation in practice and programs |
|
---|---|---|---|
Original Studies (A) |
GWAS, biomarkers, proposed new applications | clinical trials, clinical cohorts, new data on analytic or clinical validity | studies generating new process or outcome data from clinical populations, surveillance |
Research Synthesis / Modeling / Meta Analysis/ Systematic reviews / Narrative reviews (B) |
Meta analysis & systematic reviews of gene-disease associations | Evidence reports | cost-effectiveness analyses, national program evaluation |
Guidelines / Policies / Recommendations (C) |
new nomenclature, data sharing, publication standards | Clinical practice and professional guidelines | Electronic health standards, reporting requirements, ethical standards |
Tools/ Methods / Training / Education / Decision Support (D) |
research road maps, databases, software, training tools | modeling methods, databases, methods for systematic review | clinical algorithms, provider and patient education materials |