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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Clin Cancer Res. 2014 Apr 29;20(13):3521–3530. doi: 10.1158/1078-0432.CCR-14-0395

Fig. 4. Effects of Amoxapine on CPT-11-induced diarrhea, survival and tumor growth in tumor-bearing mice.

Fig. 4

A, Amoxapine treatment successfully delayed or suppressed CPT-11-induced diarrhea in tumor-bearing mice. Amoxapine 1mg/kg/day (Amox-1mg) or 5mg/kg/day (Amox-5mg), or inhibitor I 1mg/kg/day (Inhibitor-I) was orally administered twice per day along with daily i.p. CPT-11 treatment. N=15 mice per group. * p<0.05; **p<0.01, by Fisher Exact Test. B, Amoxapine treatment improved the survival of CPT-11-treated tumor-bearing mice. By the Log-rank test, CPT-11 vs. Amox-5mg, p=0.004. C, Amoxapine in combination with CPT-11 achieved addictive effect in suppressing tumor growth. Amoxapine was gavaged at 1mg/kg/day or 5mg/kg/day for 12 days with daily i.p. injection of CPT-11. Tumor volumes were estimated by the formula π/6 × a2 × b, where a is the short axis, and b the long axis. * p<0.05; **p<0.01, by Two-way ANOVA analysis, taking time and group as factors. Sigma Plot software was used to calculate the P value.