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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Cell Metab. 2014 Jun 12;20(1):103–118. doi: 10.1016/j.cmet.2014.05.005

Figure 1. Reduced fat mass and glucose tolerance in dnTNF tg mice.

Figure 1

(A) X-Gal-LacZ stained LPS-injected Adipochaser IWAT (blue=preexisting adipocytes, white=new adipocytes) (B-C) Leptin and body weight change after i.p. injection with 0.3 mg/kg LPS in dnTNF tg and wildtype female mice. (D) IWAT and GWAT weight in relation to body weight in chow (top) and HFD-fed (bottom) male dnTNF tg and wildtype controls. (E-H) Body weight, glucose tolerance test, serum adiponectin and SAA-levels in male dnTNF tg and littermate controls after 11 weeks HFD-feeding. (I) Representative Trichrome stain of IWAT in male dnTNF tg and littermate controls after 11 weeks HFD-feeding. (J) Representative perilipin (red) and mac2 (brown) immunostain in GWAT after 22 weeks HFD-feeding in male dnTNF tg and littermate control. Error bars represent SEM, a p-value <0.05 according to student t-test was considered as significant and is indicated by */#; **/##: p<0.01; ***/###: p<0.001 (* = Difference in between genotype, # = Difference from initial weight). P-values in red indicate difference between groups during the indicated time course according to repeated measurement ANOVA.