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. 2014 Jun 18;45(1):66. doi: 10.1186/1297-9716-45-66

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Copyright © 2014 Wei et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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H5N1 HPAIV NS1 interferes with chIFN-β and chIRF-7 induction. The DEF cells were cotransfected with (A) pGL3-chIFNβ-Luc or (B) pGL3-chIRF-7-Luc and the pTK-RL plasmid and with pCAGGS-MDA5-CARD and with pCAGGS-DK212-NS1 or with the empty plasmid. Dual-luciferase assays were performed after 36 h. The DEF cells were cotransfected with (C) pGL3-chIFNβ-Luc or (D) pGL3-chIRF-7-Luc and the pTK-RL plasmid. After 12 h, the cells were infected with DK212 or rDK212-ΔNS1 at different doses. Dual-luciferase assays were performed after 24 h.