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. 2014 Jun 18;45(1):66. doi: 10.1186/1297-9716-45-66

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Copyright © 2014 Wei et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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H5N1 HPAIV NS1 interferes with antiviral molecules, proinflammatory cytokines and RLR induction. The DEF cells were cotransfected with pCAGGS-MDA5-CARD and with pCAGGS-DK212-NS1 or with the empty plasmid. The control group was only transfected with pCAGGS. After 24 h quantitative real-time PCR tests of antiviral molecules (OAS, PKR and Mx), proinflammatory cytokines (IL-1β, IL-2, IL-6, IL-8, IFN-α and IFN-γ) and RLR (RIG-I and LGP2) were performed. *The difference (P < 0.05) between the experimental and control group. Error bars indicate standard deviations.