Figure 4.

Measurement of spontaneous activities and exploratory behaviors in an open field. Mice were placed in a quiet black chamber with dim light, and the time spent for each type of movements, i.e., (A) resting (below 100 cm/sec), (B) slow-moving (100~300 cm/sec), and (C) fast-moving (300~500 cm/sec), was recorded for 5 min for each mouse. Time interval between movements was 5 sec. Data are presented as mean±SEM. A value of P<0.05 (^*) was considered to be statistically significant compared to control.