Do early life exposures (diet, activity, adiposity) before menarche modify the short-term adverse effect of first birth? Do early life exposures from menarche to first pregnancy modify the short-term adverse effect of first birth?
Does adolescent diet (fiber, vegetable protein, peanuts, soy, etc.) or alcohol, modify the rate of risk accumulation from menarche to first birth?
Does higher peak height growth velocity explain international differences in breast cancer not fully explained by secular trends in age at menarche and parity?
Does the reduced peak height velocity seen in children who had higher levels of adiposity at ages 5 and 10 convey the lifelong protection from this adiposity, and if so, can these mechanisms inform prevention strategies?
Do components of in utero exposures or lifestyle before menarche drive increased risk of proliferative benign breast disease and other established intermediate endpoints (e.g., mammographic density)?
How can we account for the problem of overdiagnosis when we evaluate potential preventive strategies?
Are there reliable, early markers of breast cancer risk that can be used as surrogate outcomes in ongoing prospective studies of early-life exposures?
Do the effects of early life exposures on risk of breast cancer vary across the molecularly defined subtypes of breast cancer? Can we identify new approaches to breast cancer prevention by focusing on uncommon but aggressive types of breast cancer?
Do genetic polymorphisms modify the effects of breast cancer risk factors? Is it possible to identify those girls and women for whom avoidance of a particular risk factor is especially important?
Do early life exposures induce morphologic (not including BBD) and/or molecular changes that make the breast more susceptible to cancer?
Do early life exposures to modifiable factors affect lifelong breast cancer risk among women with family history of breast cancer?
