Fig. 2.

Qualitative reproduction of the experimental results reported by Shu et al. (2003) with the network model. Data points are the average of 5 trials. Two depolarizing stimuli, separated by the interstimulus interval, where applied, see Fig. 1. The peaks just before the transition to shorter up state durations that are visible in every curve are an artifact stemming from a heterogenous network response like the one shown in Fig. 7. Top weak stimuli, e.g. I _s = 0.1 μA, that already cause strong resetting only reduce the up state duration, independent of phase. Increasing the stimulus strength reduces the up state more the more the two stimuli are apart, until the second stimulus directly terminates an up state. For certain stimulus strengths the second stimulus ends an up state immediately for almost all interstimulus intervals. Bottom in our simulations it was possible to evoke up state like network behavior also with very high stimulus strengths. This was different from mere after spiking. The higher the stimulus strength was the larger the interstimulus interval had to be in order to reduce up state durations. This reversed tendency is not covered by (Shu et al. 2003) and remains to be tested experimentally