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Trial design. *Dose escalation to 50 mg once daily and/or reduction to 40, 30, then 20 mg once daily. †Dose can be escalated to 50 mg/m2 weekly and/or reduction to 40, 30, then 20 mg/m2 weekly. HNSCC = head and neck squamous cell carcinoma; CT = chemotherapy; MTX = methotrexate; PFS = progression-free survival.
