Fig. 2.

Changes in anthropometric and laboratory variables. Data are shown as changes from baseline in response to the regimen of six (A6) and two meals (B2) a day. Data are mean ± 95% CI. Significance of the factor treatment (assessed by 2 × 2 crossover ANOVA) is indicated by: *p < 0.05; **p < 0.01; ***p < 0.001; NS, non-significant. (a) Δ Weight, n = 54, (b) Δ HFC, n = 48, (c) Δ Fasting plasma glucose, n = 54, (d) Δ Fasting plasma C-peptide, n = 54, (e) Δ Fasting plasma glucagon, n = 54, (f) Δ HbA_1c, n = 54, (g) Δ MCR, n = 49, (h) Δ Insulin sensitivity (OGIS), n = 51, (i) Δ REE, n = 52. To convert values for HbA_1c in % into mmol/mol, subtract 2.15 and multiply by 10.929