Table 5.

Concentration of 1C-related metabolites in vitamin B-6 adequate cells and cells in a vitamin B-6 deficiency with or without concurrent oxidative stress predicted using a mathematical model of 1C metabolism (31)

	Vitamin B-6 Deficiency	Vitamin B-6 Deficiency with Oxidative Stress	Vitamin B6 Adequate
Folate forms, total
THF	11.4	10.7	8.7
5,10-Methylene-THF	0.6	0.6	0.8
Sum, THF + 5,10-methylene-THF	12	11.3	9.5
5,10-Methenyl-THF	0.5	0.5	0.6
10-Formyl-THF	4.8	4.7	6.5
Sum, 10-formyl + 5,10-methenyl-THF	5.3	5.2	7.1
5-Methyl-THF	2.7	3.7	3.4
DHF	0.023	0.021	0.029
1C metabolites, total
Serine	1,080	1,100	951
Glycine	2,620	2,720	1,200
Sarcosine	8.96	7.13	9.16
Dimethylglycine	0.69	0.55	0.71
Cystathionine	102	105	36.9
Cysteine	193	155	195
Formate	8.3	8.77	13.1
Glutathione (reduced)	6,550	7,330	6,591
Glutathione (oxidized)	61.1	108	61.3
Glutathione (total)	6,610	7,440	6,650
Methionine	50.9	48.4	41.2
S-adenosylmethionine	77.8	66.9	81.2
S-adenosylhomocysteine	22.4	17.8	19.1
Homocysteine	1.31	1.26	1.12

Values are in μmol/l. DHF, dihydrofolate.