Table 5.
Concentration of 1C-related metabolites in vitamin B-6 adequate cells and cells in a vitamin B-6 deficiency with or without concurrent oxidative stress predicted using a mathematical model of 1C metabolism (31)
| Vitamin B-6 Deficiency | Vitamin B-6 Deficiency with Oxidative Stress | Vitamin B6 Adequate | |
|---|---|---|---|
| Folate forms, total | |||
| THF | 11.4 | 10.7 | 8.7 |
| 5,10-Methylene-THF | 0.6 | 0.6 | 0.8 |
| Sum, THF + 5,10-methylene-THF | 12 | 11.3 | 9.5 |
| 5,10-Methenyl-THF | 0.5 | 0.5 | 0.6 |
| 10-Formyl-THF | 4.8 | 4.7 | 6.5 |
| Sum, 10-formyl + 5,10-methenyl-THF | 5.3 | 5.2 | 7.1 |
| 5-Methyl-THF | 2.7 | 3.7 | 3.4 |
| DHF | 0.023 | 0.021 | 0.029 |
| 1C metabolites, total | |||
| Serine | 1,080 | 1,100 | 951 |
| Glycine | 2,620 | 2,720 | 1,200 |
| Sarcosine | 8.96 | 7.13 | 9.16 |
| Dimethylglycine | 0.69 | 0.55 | 0.71 |
| Cystathionine | 102 | 105 | 36.9 |
| Cysteine | 193 | 155 | 195 |
| Formate | 8.3 | 8.77 | 13.1 |
| Glutathione (reduced) | 6,550 | 7,330 | 6,591 |
| Glutathione (oxidized) | 61.1 | 108 | 61.3 |
| Glutathione (total) | 6,610 | 7,440 | 6,650 |
| Methionine | 50.9 | 48.4 | 41.2 |
| S-adenosylmethionine | 77.8 | 66.9 | 81.2 |
| S-adenosylhomocysteine | 22.4 | 17.8 | 19.1 |
| Homocysteine | 1.31 | 1.26 | 1.12 |
Values are in μmol/l. DHF, dihydrofolate.