Fig. 7.

Different magnitude inhibition of PAF-induced Lp increases by the Rho kinase inhibitor in normal and diabetic venules. A: the overlay of 2 individual experiments conducted in diabetic venules, demonstrating the time course and the magnitude differences in PAF-induced Lp increases, with and without the application of Rho kinase inhibitor Y27632. B: summarized data showing that in diabetic venules, the application of the Rho kinase inhibitor Y27632 (30 μM) restored the increased basal Lp and attenuated PAF-induced peak Lp by >90% (n = 6). C: in normal rat venules, Y27632 did not affect basal Lp but reduced PAF-induced Lp increases by ∼70% (n = 4). *Significant increases from control; †significant decreases from positive control.