Fig. 7.
Effect of the pharmacologic inhibitors on basal Mf of NHE3. Effects on the apical NHE3 Mf in OK cells as above of the inhibitors used to determine the signaling through which LPA/LPA5R (3 μM) stimulates NHE3 activity. All experiments were compared with untreated or solvent controls done on the same day with P values representing comparison with experimental controls; n ≥ 3 for all agents. The agents that significantly increased the NHE3 Mf under basal conditions included the ERK inhibitor U0126; the PLC inhibitor U73122; the general PKC inhibitor GF109293X; the conventional and novel PKC inhibitor Gö6983; and the conventional PKC inhibitor Gö6976. *P < 0.05.