Table 1. μCT analyses of cortical bone of vehicle-treated and GSI XII-treated MOPC315.BM mice (36 days of GSI XII treatment).
| Variable | GSI XII n=9 | s.d. | Vehicle n=13 | s.d. | P-value | Signif. diff. |
|---|---|---|---|---|---|---|
| Ct.area (mm2) | 0.78 | 0.07 | 0.78 | 0.04 | 0.918 | NS |
| Tt.area (mm2) | 0.95 | 0.07 | 0.97 | 0.04 | 0.444 | NS |
| Ct.Po.Ar (mm2) | 0.16 | 0.02 | 0.18 | 0.02 | 0.018 | Yes |
| Ct.Th (mm) | 0.11 | 0.01 | 0.11 | 0.01 | 0.589 | NS |
| Ct. vBMD (mg HA/cm3) | 917 | 30 | 902 | 24 | 0.234 | NS |
Abbreviations: Ar, area; Ct., cortical; μCT, microcomputed tomography; GSI, γ-secretase inhibitor; HA, hydroxylapatite; Po., porosity; Th, thickness; Tt., total; vBMD, volumetric bone mineral density.
Two-tailed t-test was used for statistical analysis. Significant P-value is indicated in bold.