Table 2. CD33 and CD123 expression by cytogenetics and molecular alterations.
| Cytogenetics/mutation | Meana CD33 expression | S.d. | N | % Positive (GeoMean ratio >10) | P-value unpaired two-tailed t-test |
|---|---|---|---|---|---|
| CD33 | |||||
| FLT3 wt | 38.5 | 31.9 | 219 | 88.1 | |
| FLT3 mut | 55.0 | 35.6 | 58 | 93.1 | 7.19E−04 |
| NPM1 wt | 33.9 | 27.7 | 190 | 85.3 | |
| NPM1 mut | 63.3 | 37.4 | 62 | 100.0 | 2.87E−10 |
| CEBPA wt | 42.0 | 32.8 | 220 | 90.0 | |
| CEBPA mut | 32.1 | 16.1 | 14 | 92.9 | 0.26 |
| t(15;17) neg | 40.7 | 33.1 | 234 | 88.0 | |
| t(15;17) pos | 54.4 | 24.8 | 10 | 100.0 | 0.20 |
| t(8;21) neg | 41.8 | 32.8 | 242 | 88.8 | |
| t(8;21) pos | 16.2 | 9.2 | 11 | 90.9 | 0.01 |
| inv(16) neg | 41.3 | 33.1 | 241 | 88.8 | |
| inv(16) pos | 27.1 | 14.4 | 12 | 91.7 | 0.14 |
| Monosomy 5 neg | 40.0 | 32.3 | 247 | 88.7 | |
| Monosomy 5 pos | 73.0 | 35.1 | 5 | 100.0 | 0.03 |
| del(5q) neg | 41.1 | 33.1 | 235 | 88.9 | |
| del(5q) pos | 33.7 | 25.4 | 18 | 88.9 | 0.35 |
| Monosomy 7 neg | 40.7 | 32.5 | 238 | 89.1 | |
| Monosomy 7 pos | 40.4 | 35.8 | 14 | 85.7 | 0.97 |
| inv(3q) neg | 40.8 | 32.7 | 250 | 89.2 | |
| inv(3q) pos | 26.5 | 30.4 | 2 | 50.0 | NA |
| t(3;3) neg | 40.2 | 31.8 | 246 | 89.0 | |
| t(3;3) pos | 61.0 | 58.7 | 6 | 83.3 | 0.12 |
| t(6;9) neg | 40.6 | 32.8 | 250 | 88.8 | |
| t(6;9) pos | 47.0 | 8.5 | 2 | 100.0 | NA |
| t(6;11) neg | 40.7 | 32.7 | 251 | 88.8 | |
| t(6;11) pos | 41.0 | NA | 1 | 100.0 | NA |
| CD123 | |||||
| FLT3 wt | 19.8 | 14.4 | 208 | 76.9 | |
| FLT3 mut | 44.8 | 39.2 | 53 | 98.1 | 1.31E−12 |
| NPM1 wt | 20.6 | 17.2 | 179 | 76.0 | |
| NPM1 mut | 40.6 | 36.3 | 56 | 94.6 | 4.74E−08 |
| CEBPA wt | 26.3 | 26.0 | 205 | 79.0 | |
| CEBPA mut | 16.4 | 6.4 | 14 | 100.0 | 0.15 |
| t(15;17) neg | 25.3 | 25.1 | 221 | 80.1 | |
| t(15;17) pos | 33.3 | 13.6 | 9 | 100.0 | 0.34 |
| t(8;21) neg | 25.8 | 24.9 | 228 | 82.9 | |
| t(8;21) pos | 13.5 | 11.3 | 11 | 36.4 | 0.11 |
| inv(16) neg | 25.4 | 24.8 | 227 | 80.2 | |
| inv(16) pos | 21.4 | 18.8 | 12 | 91.7 | 0.58 |
| Monosomy 5 neg | 25.4 | 24.7 | 232 | 80.6 | |
| Monosomy 5 pos | 21.4 | 17.5 | 5 | 80.0 | 0.72 |
| del(5q) neg | 25.5 | 25.2 | 221 | 80.1 | |
| del(5q) pos | 21.3 | 13.4 | 18 | 83.3 | 0.48 |
| Monosomy 7 neg | 25.3 | 24.8 | 224 | 80.4 | |
| Monosomy 7 pos | 24.2 | 20.5 | 13 | 84.6 | 0.88 |
| inv(3q) neg | 25.4 | 24.6 | 235 | 80.9 | |
| inv(3q) pos | 7.5 | 4.9 | 2 | 50.0 | NA |
| t(3;3) neg | 25.6 | 24.8 | 231 | 81.0 | |
| t(3;3) pos | 14.0 | 7.2 | 6 | 66.7 | 0.26 |
| t(6;9) neg | 25.4 | 24.6 | 235 | 80.9 | |
| t(6;9) pos | 13.5 | 14.8 | 2 | 50.0 | NA |
| t(6;11) neg | 25.2 | 24.6 | 236 | 80.5 | |
| t(6;11) pos | 42.0 | NA | 1 | 100.0 | NA |
Abbreviations: CEBPA, CCAAT/enhancer-binding protein-α FLT3, FMS-related tyrosine kinase 3; mut, mutant; ITD, internal tandem duplication; NA, not available; neg, negative; NPM1, nucleophosmin; pos, positive; wt, wild type. Bold entries are statistically significant.
a
Arithmetic mean of GeoMean ratios.