Table 1. TargetScan-predicted target genes for candidate miRNAs differentially expressed between extramedullary versus medullary plasmacytomas.
| Pathway | No. in ref. | No. in list | Expected | +/−a | P-value (Bonferroni-corrected) |
|---|---|---|---|---|---|
| Unclassified | 19 446 | 1985 | 2132.42 | − | 1.51E−17 |
| Gonadotropin-releasing hormone receptor pathway | 228 | 76 | 25 | + | 1.96E−14 |
| EGF receptor signaling pathway | 123 | 43 | 13.49 | + | 1.89E−08 |
| FGF signaling pathway | 115 | 40 | 12.61 | + | 9.54E−08 |
| PDGF signaling pathway | 132 | 42 | 14.47 | + | 4.65E−07 |
| Angiogenesis | 152 | 44 | 16.67 | + | 3.01E−06 |
| Ras pathway | 73 | 24 | 8.01 | + | 6.33E−04 |
| TGF-beta signaling pathway | 95 | 28 | 10.42 | + | 7.92E−04 |
| Insulin/IGF pathway–protein kinase B signaling cascade | 37 | 16 | 4.06 | + | 1.00E−03 |
| Apoptosis signaling pathway | 113 | 31 | 12.39 | + | 1.04E−03 |
| Axon guidance mediated by netrin | 34 | 15 | 3.73 | + | 1.54E−03 |
| Insulin/IGF pathway–mitogen-activated protein kinase kinase/MAP kinase cascade | 32 | 14 | 3.51 | + | 3.31E−03 |
| Integrin signaling pathway | 175 | 40 | 19.19 | + | 3.57E−03 |
| Metabotropic glutamate receptor group III pathway | 56 | 19 | 6.14 | + | 4.11E−03 |
| PI3 kinase pathway | 47 | 17 | 5.15 | + | 4.97E−03 |
Abbreviation: ref., reference.
Only pathways with Bonferroni-corrected P<0.005 are listed. Pathways listed in bold type are unique to the candidate miRNA list (not overlapping in the control miRNA list, Supplementary Table 3).
a
‘+' indicates that pathways are overrepresented in the analyzed miRNA target gene list compared with the ‘ref.' Homo sapiens gene list. ‘−' indicates that pathways are underrepresented.