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. Author manuscript; available in PMC: 2014 Jul 3.
Published in final edited form as: Cytokine Growth Factor Rev. 2013 Dec 24;25(2):175–183. doi: 10.1016/j.cytogfr.2013.12.008

Fig. 1.

Fig. 1

Structures of CARMA1, Bcl10 and MALT1. (A) Domain organization of CARMA1, Bcl10 and MALT1. CARD, caspase recruitment domain; PDZ, PSD95, DLG and ZO1 homology domain; SH3, Src homology 3 domain; MAGUK, membrane-associated guanylate kinase domain; S/T rich, Ser/Thr rich region; DD, death domain; Ig, immunoglobulin-like domain. The number of residues in each protein is labeled at the end. (B) Crystal structure of CARMA1 CARD domain (PDB 4LWD). (C) NMR structure of Bcl10 mutant E53D (PDB 2MB9). (D) Crystal structure of MALT1 death domain (PDB 2G7R). (E) Crystal structure of MALT1 tandem Ig1-Ig2 domains (PDB 3K0W). (F) Crystal structure of MALT1 paracaspase-Ig3 domains in complex with irreversible peptide inhibitor Z-VRPR-FMK shown in red (PDB UOA).