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. Author manuscript; available in PMC: 2014 Jul 3.
Published in final edited form as: Cytokine Growth Factor Rev. 2013 Dec 24;25(2):175–183. doi: 10.1016/j.cytogfr.2013.12.008

Fig. 3.

Fig. 3

The structure of current inhibitors of MALT1. (A) Phenothiazine derivatives (Mepazine, Thioridazine and Promazine) that inhibit MALT1 activity. (B) Crystal structure of MALT1 in complex with Thioridazine shown in cyan stick. Thioridazine binds at the interface between paracaspase and Ig3 domains and allosterically inhibits the activity of MALT1. (C) MI-2 is a novel compound that specifically inhibits MALT1 protease activity.