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. 2014 Jul 3;4:5550. doi: 10.1038/srep05550

Figure 2. Effect of anti gB antibody-conjugated nanoparticles on CMV infection of HF cells.

Figure 2

(A–H) gB-GNP were tested for their efficacy to block human cytomegalovirus (CMV) infection of primary HF cells. Star (GNPst), sphere (GNPsp) or popcorn (GNPop) shaped nanoparticles were added (50 ng antibody total) to HF at the time of infection, or the cells were mock treated (UT). eGFP fluorescence or bright-field (BF) images were recorded at 5 dpi. eGFP signal emanates from the virus genome. (I–P) gB-GNPop were tested for their efficacy to block the spread of cytomegalovirus infection in HF cells. gB-GNPop (50 ng antibody total) were added to HF at one dpi or the cells were mock treated (UT). eGFP fluorescence or bright-field (BF) images were recorded at 5 dpi. (Q) Single step growth curve analysis of Towne strain of CMV in HF either treated with gB conjugated GNPop (Topwne-Bac + GNPop, 50 ng antibody total) or mock treated (Towne-Bac).