Fig. 6.

FasL-expressing CD8⁺ T lymphocytes enhance alveolar macrophage (AMΦ) apoptosis and clearance during the resolution of LPS-induced inflammation. Rag-1^−/− lymphocyte-deficient mice were treated with LPS immediately followed by intravenous adoptive transfer of CD4⁺- or CD8⁺-purified T lymphocytes. A: number of AMΦ in BAL fluid on day 9 following intratracheal LPS treatment and concurrent intravenous adoptive transfer of FasL-sufficient (WT) CD4⁺ or CD8⁺ T lymphocytes or FasL mutant (gld) CD8⁺ lymphocytes. B: AMΦ activated caspase-3 expression on day 9 following LPS treatment and T-lymphocyte adoptive transfer; n = 3–7 mice per group; 2 replicates, with exception of CD8⁺ gld = 1 replicate. *P < 0.05.