Table 3.

Association between OA and composite BMD risk score

	Unadjusted Odds Ratios (95% Confidence Intervals)
	OAI	JoCo	Combined
Quintile 1	Ref.	Ref.	Ref.
Quintile 2	1.08 (0.85–1.37)	1.15 (0.83–1.59)	1.10 (0.91–1.34)
Quintile 3	1.26 (0.99–1.60)	0.99 (0.71–1.37)	1.15 (0.95–1.40)
Quintile 4	1.05 (0.83–1.34)	1.16 (0.84–1.61)	1.09 (0.90–1.32)
Quintile 5	1.33 (1.04–1.70)	1.04 (0.75–1.43)	1.21 (1.00–1.47)
Beta, P-value for effect of risk score on OA, by logistic regression	0.326, P=0.033*	0.036, P=0.367**	0.05, P=0.162

Composite risk score consists of all BMD associated variants.

^†Effect of risk score, modeled as a continuous variable, on OA using logistic regression.

^*Adjusted for age, sex, BMI, study site, and PCs

^**Adjusted for age, sex, BMI and PCs