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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Food Chem Toxicol. 2014 Mar 20;68:196–203. doi: 10.1016/j.fct.2014.03.015

Figure 5. No effect on the T cell proliferative response in Elmiron® treated mice.

Figure 5

(A) Anti-CD3 mediated proliferation: Splenocytes were cultured in the presence or absence of anti-CD3 antibody for 3 days. There were no significant differences in the ability of Elmiron®-treated T cells to proliferate in response to signaling through the T cell receptor initiated by anti-CD3 antibody. (B) MLR assay: Splenocytes were cultured for 5 days in the presence of mitomycin C-treated DBA/2 allogenic stimulator cells. No consistent changes in the ability of host T cells (responders) to recognize and proliferate in response to allogeneic stimulator cells were observed. The positive control CP was administered i.p. on days 25–28. CPM=counts per minute. Data are represented as Mean ± SEM (n=7–8). * p≤ 0.05, ** p≤ 0.01 as compared to the vehicle control.