Table 1. DAVID pathway analysis of differentially expressed genes (q<0.1).
| Time | Direction of effect | Enrichment | Annotation cluster description |
|---|---|---|---|
| 24 h | Downregulation (183 genes) | 3.04 | Extracellular matrix |
| 2.92 | Positive regulation of transcription | ||
| 2.61 | Neuron differentiation/projection | ||
| 2.55 | Extracellular signaling | ||
| Upregulation (126 genes) | 2.75 | Cell cycle | |
| 48 h | Downregulation (239 genes) | 10.75 | Cell cycle |
| 7.16 | DNA replication | ||
| 4.74 | Lumen/membrane enclosed | ||
| 4.42 | Cell cycle checkpoint | ||
| 3.31 | Chromosome segregation | ||
| 3.04 | Mitotic checkpoint/chromosome | ||
| 3.01 | Microtubule/spindle organization | ||
| 2.79 | DNA binding | ||
| Upregulation (376 genes) | 15.98 | Signaling | |
| 12.07 | Transmembrane | ||
| 10.47 | Cell adhesion | ||
| 5.87 | Plasma membrane | ||
| 4.41 | EGF-like | ||
| 4.18 | MHC class II/antigen processing | ||
| 3.89 | Ion transport/gated channels | ||
| 3.79 | Immunoglobulin-like | ||
| 3.63 | Calcium ion binding/ion binding | ||
| 3.21 | Angiogenesis | ||
| 2.80 | Cell junction/synapse | ||
| 2.58 | Synaptic transmission | ||
| 2.55 | Matrix adhesion/integrins | ||
| 2.52 | Extracellular matrix |
Abbreviations: EGF, epidermal growth factor; MHC, major histocompatibility complex. Pathway analysis from DAVID. As many annotated pathways contain overlapping genes, DAVID combines such pathways into clusters. Column 4 shows our labels for these clusters. Individual pathways are reported in Supplementary Tables S5a and S6b.