Table 3. Enrichment of schizophrenia GWAS results and genes with differential expression after overexpression of miR-137.
| Time | DE genes (q<0.1) | Enrichment P-value |
|---|---|---|
| 24 h | All | >0.1 |
| Downregulation | >0.1 | |
| Upregulation | >0.1 | |
| 48 h | All | 0.014 |
| Downregulation | 0.005 | |
| Upregulation | 0.011 |
Abbreviation: GWAS, genome-wide association study.
P-values from INRICH evaluating the enrichment of lower GWAS P-values (P<0.01)6 to differentially expressed genes (q<0.1) from miR-137 overexpression. The extended major histocompatibility complex region (chr6:25–34 mb) was excluded due to its high gene density, extended linkage disequilibrium and strong GWAS signal in schizophrenia. Boldface shows P<0.01.