Table 2. Respiratory parameters assessed in PBMCs of MD patients and control subjects.
| Variables |
Groups |
T-value | U-value | Z-value | df | P-value | |
|---|---|---|---|---|---|---|---|
| MD (n = 19) | Controls (n = 19) | ||||||
| Routine respiration (R)a | 3.35±1.44 | 4.03±1.04 | −1.80 | 38.3 | 0.040 | ||
| LEAK respiration (L) | 1.83±1.06 | 1.47±0.76 | 133.5 | −1.372 | 0.085 | ||
| Uncoupled respiration (E) | 5.55±2.10 | 8.04±2.57 | 68.0 | −3.284 | 5.11 × 10−4 | ||
| Residual oxygen consumption (ROX) | |||||||
| Rotenone | 0.55±1.2 | 0.33±0.60 | 135.0 | −1.330 | 0.092 | ||
| Antimycin A | 0.54±0.66 | 0.45±0.39 | 162.0 | −0.541 | 0.294 | ||
| ATP turnover-related respiration (R−L) | 1.34±0.81 | 2.54±0.78 | −4.64 | 36 | 2.25 × 10−5 | ||
| Spare respiratory capacity (E−R) | 2.38±1.41 | 4.03±2.26 | 98.0 | −2.409 | 0.008 | ||
| Routine flux control ratio (R/E) | 58.00±15.69 | 53.00±18.24 | 146.0 | −1.007 | 0.157 | ||
| Coupling efficiency ((R−L)/R) | 41.18±15.71 | 63.83±13.76 | −4.73 | 36 | 1.70 × 10−5 | ||
Abbreviations: MD, major depression; PBMCs, peripheral blood mononuclear cells.
Values are given as mean±s.d. pmol O2 per s·ml for the upper part and mean±s.d. % for the lower part.
a
Routine respiration was assessed in n = 22 MD patients and n = 22 control subjects. U-value, Z-value are listed for one-tailed Mann–Whitney U test, T-value and df are listed for one-tailed Student's independent t-test. Parametric and nonparametric tests were applied where appropriate. Bold P-values indicate significance on an alpha level of 0.05.