Table 3. Treatment-associated changes in clinical variables by genotype groups.
| t1(pretreatment) | t2(4 months) | t3 (10 months) | Change scorea | Effect size Cohen's Db | |
|---|---|---|---|---|---|
| N PTSD diagnosis (%) | |||||
| C/C | 13 (100) | 4 (31) | 0 (0)c | ||
| T allele carrier | 30 (100) | 7d (29) | 13 (43) | ||
| Mean PDS score (s.d.) | |||||
| C/C | 17.69 (4.44) | 8.15 (5.00) | 3.92 (2.78) | −13.58 (6.37) | 3.72 |
| T allele carrier | 16.63 (4.94) | 7.90 (6.03) | 9.37 (6.73) | −7.27 (5.60) | 1.23 |
| Mean M.I.N.I. suicidality score (s.d.) | |||||
| C/C | 12.69 (8.31) | 5.31 (6.47) | 2.08 (4.94) | −11.08 (8.67) | 1.55 |
| T allele carrier | 11.90 (11.21) | 8.45 (10.60) | 7.37 (8.31) | −4.53 (6.85) | 0.45 |
| Mean PDS intrusions score (s.d.) | |||||
| C/C | 4.85 (2.51) | 2.54 (1.51) | 1.50 (1.68) | −3.08 (3.32) | 1.57 |
| T allele carrier | 4.53 (2.30) | 1.83 (2.25) | 2.53 (2.36) | −2.00 (3.25) | 0.86 |
| Mean PDS avoidance score (s.d.) | |||||
| C/C | 6.38 (2.10) | 2.46 (1.94) | 0.83 (1.27) | −5.50 (2.54) | 3.20 |
| T allele carrier | 6.07 (2.03) | 2.52 (2.23) | 3.17 (2.36) | −2.90 (2.29) | 1.32 |
| Mean PDS hyperarousal score (s.d.) | |||||
| C/C | 6.46 (2.15) | 3.15 (2.41) | 1.58 (1.00) | −5.00 (2.45) | 2.92 |
| T allele carrier | 6.03 (2.76) | 3.55 (2.68) | 3.67 (2.68) | −2.37 (2.51) | 0.87 |
Abbreviations: M.I.N.I., Mini International Neuropsychiatric Interview; PDS, Posttraumatic Diagnostic Scale; PTSD, Posttraumatic Stress Disorder.
a
Change score describes the difference between pretreatment and 10-month follow-up assessment.
b
Cohen's D describes the within-group treatment effect size between pretreatment and 10-month follow-up assessment.
c
One individual was not found for 10-month follow-up.
d
One individual was not found for 4-month follow-up.