Table 3. Formate and methanol kinetics in the patients treated on CVVHD12, 13, 14, 15, 16, 17, 18, 19 and CVVHDF20, 21, 22, 23, 24.
| Patient | Methanol t ½, h | R2 methanol | Formate t ½, h | R2 formate | Observation time during CVVHD/HDF, h | Blood FR, ml/min | Dialysate FR, ml/h | Substitution fluid FR, ml/h | Dialyzer type | Dialyzer surface area, m2 | Anticoagulation | Dialysate temperature | Number of data points | Complications | Number of circuits | Frequency of circuit blotting | Ultrafiltration, ml/h |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 12 | 11.7 | 0.99 | 5.9 | 0.92 | 34.0 | 100 | 2000 | - | Aquarius | 1.2 | Citrate | 36.5 | 8 | 0 | 1 | 0 | - |
| 13 | 9.8 | 0.99 | 4.5 | 1.00 | 32.0 | 130 | 2400 | - | Multifiltrate Fresenius | 1.8 | Citrate | 38.0 | 4 | 0 | 1 | 0 | - |
| 14 | 7.7 | 0.94 | 5.9 | 0.88 | 32.0 | 130 | 2500 | - | Multifiltrate Fresenius | 1.8 | Citrate | 36.5 | 6 | 0 | 1 | 0 | - |
| 15 | 6.8 | 0.99 | 4.1 | 1.00 | 32.5 | 100 | 2500 | - | Aquarius | 1.9 | Citrate | 36.5 | 6 | 0 | 1 | 0 | - |
| 16 | 9.0 | 0.99 | 2.4 | 0.97 | 26.5 | 250 | 2500 | - | Multifiltrate Fresenius | 1.8 | Hep | 39.0 | 5 | 0 | 1 | 0 | - |
| 17 | 5.6 | 0.95 | 2.1 | 0.96 | 26.0 | 150 | 3000 | - | Multifiltrate Fresenius | 1.8 | Citrate | 36.5 | 6 | 0 | 1 | 0 | - |
| 18 | 5.8 | 0.99 | 2.4 | 1.00 | 28.5 | 200 | 4800 | - | Multifiltrate Fresenius | 1.8 | Citrate | 38.0 | 4 | 0 | 1 | 0 | - |
| 19 | 5.3 | 0.96 | 1.9 | 1.00 | 31.5 | 200 | 4800 | - | Multifiltrate Fresenius | 1.8 | Citrate | 38.0 | 4 | 0 | 1 | 0 | - |
| 20 | 10.6 | 0.99 | 4.0 | 0.97 | 34.5 | 120 | 1000 | 1200 | Aquarius | 1.2 | Hep | 36.5 | 7 | BL | 1 | 0 | 100 |
| 21 | 8.4 | 0.95 | 6.2 | 0.98 | 29.5 | 200 | 1000 | 1200 | Multifiltrate Fresenius | 1.4 | Hep | 38.0 | 7 | 0 | 1 | 0 | 100 (24 h), 50 (5.5 h) |
| 22 | 10.0 | 0.99 | 3.2 | 0.83 | 36.0 | 150 | 1800 | 600 | Multifiltrate Fresenius | 1.8 | Citrate | 35.0 | 9 | 0 | 1 | 0 | 100 |
| 23 | 6.3 | 0.98 | 2.1 | 1.00 | 35.5 | 150 | 1800 | 600 | Aquarius | 1.9 | Hep | 36.5 | 8 | 0 | 1 | 1 | 150 |
| 24 | 8.1 | 0.98 | 1.9 | 0.85 | 37.5 | 150 | 2000 | 600 | Multifiltrate Fresenius | 1.8 | Citrate | 35.0 | 8 | 0 | 1 | 0 | 150 |
| Mean | 8.1 | 0.98 | 3.6 | 0.95 | 32.0 | 155 | 2470 | 1.75 | |||||||||
| LCL95% | 6.9 | 2.6 | 29.8 | 128 | 1750 | 1.65 | |||||||||||
| UCL95% | 9.3 | 4.6 | 34.2 | 183 | 3180 | 1.84 |
Abbreviations: BL, bleeding during HD; CI 95%, 95% confidence interval; CVVHD/HDF, continuous veno-venous hemodialysis/hemodiafiltration; FR, flow rate; LCL, the lower limit of a confidence interval at the 95% level; UCL, the upper limit of a confidence interval at the 95% level. Polysulfone dialyzer membranes have been used in all cases.