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. Author manuscript; available in PMC: 2014 Nov 12.
Published in final edited form as: Nat Commun. 2014 May 12;5:3878. doi: 10.1038/ncomms4878

Figure 7. Macrophage Tlr4 deficiency results in elevated circulating inflammatory cytokines in obese mice.

Figure 7

(a) qPCR analysis of genes in epididymal white adipose tissue (WAT, n = 5–7). (b) Plasma Tnfa, IL-6, IL-1β and Mcp1 levels in mice fed HFD for 12 weeks (n = 10–13 for Tnfα, IL-1β and Mcp1; n = 6–7 for IL-6). (c) qPCR analysis of genes involved in M2 macrophage activation in epididymal white adipose tissue (WAT, n = 5–7). (d) Plasma IL-10 level in mice on HFD. *p < 0.05, compared between Tlr4fl/fl and Tlr4ΔmΦ mice (Student’s t-test). All data are presented as means ± s.e.m.